|
KMID : 1100220120110020067
|
|
Dementia and Neurocognitive Disorders
2012 Volume.11 No. 2 p.67 ~ p.73
|
|
|
The Correlation of the White Matter Lesions and Lacunar Infarcts in Patients with Vascular Cognitive Impairment
|
|
Kim Hee-Young
Jeong Eun-Hye
Juh Ra-Hyeong
Lee Jae-Hong
|
|
|
Abstract
|
|
|
Background: Cerebral white matter lesions (WMLs) and lacunar infarcts (LIs) are mostly caused by small vessel disease (SVD). Whereas the main pathomechanism behind LIs is SVD, a variety of mechanisms could be responsible for WMLs. We tried to investigate the relationship between WMLs and LIs and the impact of subtypes of WMLs on its relationship.
Methods: We assessed 128 subjects with vascular cognitive impairment with subcortical vascular lesion (VCI-S). LI number and WML volume were determined on T1-, T2-weighted images and fluid-attenuated inversion recovery images using a semiquantitative visual scale. Cognitive function and daily functional impairment were assessed with Mini-Mental State Examination (MMSE) and the Seoul-Instrumental Activities of Daily Living (S-IADL).
Results: Of the 128 patients, 106 (82.8%) had Alzheimer’s disease with WML and 22 (17.2%) had subcortical vascular dementia. Seventy patients (54.7%) had at least one lacune. A univariate Poisson model showed that history of hypertension, history of stroke and WML volume (periventricular and deep subcortical) were associated with LIs. A multivariate Poisson model showed that increased WML volume of both types and history of hypertension were associated with LIs. Neither S-IADL score nor MMSE was significantly associated with WML volume of both types.
Conclusions: We found that LIs were associated with WMLs regardless of their types in patients with VCI-S. These findings may suggest that periventricular and deep subcortical WMLs share the same vascular pathomechanism of SVD as LIs.
|
|
|
KEYWORD
|
|
|
White matter lesions, Lacunar infarction, Vascular cognitive impairment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|